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KMID : 0356919700030010017
Korean Journal of Anesthesiology
1970 Volume.3 No. 1 p.17 ~ p.19
The effect of divided dose of atropine on the pulse rate in man

Abstract
In human volunteers, 0. 25mg of atropine was given in divided doses(0.1mg and 0. 15mg) with an interval of 15 minutes and 50 minutes
When atropine was given with an interval of 15 minutes, the first dose (0.1n;g) produced bardycardia and the second does coused slight increase of pulse rate which did no\ exceed the original rate
When atropine was given with an interval of 50 minutes, the first dose (0. lmg) produced bradycardia and the second dose marked increase of pulse rate which exceeded the original rate.
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